Modeling Metabolic Flux Within the Liver Using Nuclear Magnetic Resonance Data

Abstract: Measuring metabolic flux rates within the liver is a useful way of investigating and predicting the dynamics of metabolism occurring in the liver whose major function is energy metabolism but which also is the main site for xenobiotic metabolism, both vital functions for the host. In parallel with the NMR experimental method of measuring metabolic fluxes, we are developing a mathematical model to simulate the path of labeled glycine in the liver which will give insight to the control mechanisms behind liver metabolism and also predict the dynamics of these metabolic flux rates.